Missing all file permissions on windows server(any version) after save an office document.(Word,Excel or others)

The Microsoft support let us know that this is definitely a Defender issue going back to an update released. We had to apply this command on the PC which is using Microsoft Defender to resolve the issue:

Open Power Shell use this command

powershell

1. Enter Get-MpComputerStatus

2. check AMRunningMode 

If it is running(Microsfot Defender) that shows standard or passive mode than

key in the command in the power shell to disable the network files scanning function in Microsoft Defender.

Set-MpPreference -DisableScanningNetworkFiles $true

I wish the above procedures can help you fix  the problem. God bless you.